HLA Alleles in Breast Cancer

HLA-DQB1 and HLA-DRB1 MHC Class-II Alleles and Breast Cancer in Jordanians

Cancer becomes one of the most wide-spreading diseases nowadays (Atoum et al., 2010), breast cancer is the most common female malignancy worldwide, and the second leading cause of cancer mortality among women (Downs-Holmes and Silverman, 2011) accounting for 23% of all cancers (Liang et al., 2008) with more than one million new patients are diagnosed annually (Watanabe et al., 2010). Globally i...

Genetic susceptibility to breast cancer: HLA DQB*03032 and HLA DRB1*11 may represent protective alleles.

Tumors are believed to emerge only when immune surveillance fails. We wished to ascertain whether the failure to inherit putative protective alleles of HLA class II genes is linked to the development of breast cancer. We molecularly typed HLA DPB1, DQB1, DRB1, and DRB3 alleles in 176 Caucasian women diagnosed with early-onset breast cancer and in 215 ethnically matched controls. HLA DQB*03032 w...

HLA in breast cancer

HLA alleles in pre-menopausal breast cancer patients from western India.

BACKGROUND & OBJECTIVES Cytotoxic function of Natural Killer (NK) cells is regulated by the products of HLA class I genes. Associations between HLA alleles and risk for cancers have been suggested earlier. Several reports further emphasize the need to examine influence of HLA genotypes on risk for malignant disorders. Therefore, we undertook this study to assess the possibility of association o...

HLA –DRB1*, DQB1* Alleles In Hydatid Patients By Molecular Typing

Mosayebi M1, Dalimi Asl A2, Moazeni M3, Mosayebi Gh4 1. Ph.D Student, Department of Parasitology, Faculty of medicine, Tarbiat Modarres University 2. Professor, Department of Parasitology, Faculty of medicine, Tarbiat Modarres University 3. Professor, Department of Immunology, Faculty of medicine, Tarbiat Modarres University 4. Assistant professor, Department of Immunology, Faculty of medici...